Part 1: Phantom Blood (ファントムブラッド, Fantomu Buraddo)
Volumes 1–5, 44 chapters. In late 19th-century England, Jonathan Joestar, the young son of a wealthy landowner, meets his new adopted brother Dio Brando, who loathes him and plans to usurp his position as heir to the Joestar family. When Dio's attempts are thwarted, he transforms himself into a vampire using an ancient Stone Mask and destroys the Joestar estate. Jonathan embarks on a journey, meets new allies, and masters the Hamon (波紋, "Ripple") martial arts technique to stop Dio, who has made world domination his new goal.

Part 2: Battle Tendency (戦闘潮流, Sentō Chōryū)
Volumes 5–12, 69 chapters. In 1938, German researchers discover three lifeforms called Pillar Men, powerful humanoids responsible for the creation of the Stone Mask. The Pillar Men awaken and escape in search of the Red Stone of Aja, which will turn them into invincible superbeings. Joseph Joestar, Jonathan's grandson, unites with new allies and masters Hamon to defeat the Pillar Men.

Part 3: Stardust Crusaders (スターダストクルセイダース, Sutādasuto Kuruseidāsu)
Volumes 13–28, 152 chapters. In 1989, Dio Brando (now referred to as only "Dio") awakens after his coffin is salvaged from the ocean. Because Dio had managed to take over Jonathan's body, Stands (スタンド, Sutando) awaken in Jonathan's descendants, including Joseph, his daughter Holy Kujo, and his grandson Jotaro Kujo. Holy, however, is unable to control her own Stand, which begins to slowly kill her. Jotaro, Joseph, and their allies set out to defeat Dio before Holy's Stand takes her life, fighting off Dio's henchmen along the way.

Part 4: Diamond Is Unbreakable (ダイヤモンドは砕けない, Daiyamondo wa Kudakenai)
Volumes 29–47, 174 chapters. In 1999, the Joestar family learns that Joseph has an illegitimate son, Josuke Higashikata, who lives in the fictional Japanese town of Morioh. While visiting Morioh, Jotaro learns of a mystical Bow and Arrow that bestows Stands upon those struck by it. As they hunt down the Bow and Arrow, Josuke, Jotaro, and their allies are targeted by Stand-using serial killer Yoshikage Kira and his father Yoshihiro, who see them as a threat to the former's peace and tranquility.

Part 5: Golden Wind (黄金の風, Ōgon no Kaze)
Volumes 47–63, 155 chapters. Giorno Giovanna is the son of Dio, conceived while the vampire was in possession of Jonathan Joestar's body. In 2001, in Naples, Italy, Giorno seeks to become a mafia boss in order to eliminate drug dealers who sell their wares to children. Finding a powerful ally in Bruno Bucciarati, Giorno and Bucciarati's team rebel against the boss of the mafia to protect his daughter, Trish Una, whom he intends to kill in order to hide his identity.

Part 6: Stone Ocean (ストーンオーシャン, Sutōn Ōshan)
Volumes 64–80, 158 chapters. In 2011, near Port St. Lucie, Florida, Jotaro Kujo's daughter Jolyne Cujoh is framed for murder and sent to prison. She works together with various allies, including a child born in prison named Emporio Alniño, to hunt down the person responsible for her framing: prison chaplain Enrico Pucci, a loyalist to Dio who seeks the creation of a new universe shaped to the late vampire's will.

Part 7: Steel Ball Run (スティール・ボール・ラン, Sutīru Bōru Ran)
Volumes 81–104, 95 chapters. In the 1890 of an alternate universe, United States President Funny Valentine holds a cross-country horse race with a $50 million reward for the winner. Valentine secretly intends to use the race to gather the scattered parts of a holy corpse for his own nationalistic ends. Racers Gyro Zeppeli and Johnny Joestar uncover Valentine's ploy, and must defend themselves from both other racers and hired assassins.

Part 8: JoJolion (ジョジョリオン, Jojorion)
Volumes 105–131, 110 chapters. In 2011, in the same universe as Steel Ball Run, the town of Morioh is devastated by the 2011 Tōhoku earthquake and tsunami. Local college student Yasuho Hirose discovers an amnesiac young man buried in the rubble and puts him in the care of the Higashikata family, who give him the nickname "Josuke." As Josuke tries to uncover the secret of his past, he is also confronted by a local crime syndicate of inhuman beings dubbed Rock Humans, whose leader, Toru, seeks to use the mysterious Locacaca fruit to rise to the apex of society.