Babylon was the capital city of the ancient Babylonian Empire, which itself is a term referring to either of two separate empires in the Mesopotamian area in antiquity. These two empires achieved regional dominance between the 19th and 15th centuries BC, and again between the 7th and 6th centuries BC. The city, built along both banks of the Euphrates river, had steep embankments to contain the river's seasonal floods. The site of the ancient city lies just south of present-day Baghdad.

The earliest known mention of Babylon as a small town appears on a clay tablet from the reign of Shar-Kali-Sharri (2217–2193 BC) of the Akkadian Empire.[2] Babylon was merely a religious and cultural centre at this point and neither an independent state nor a large city; like the rest of Mesopotamia, it was subject to the Akkadian Empire which united all the Akkadian and Sumerian speakers under one rule. After the collapse of the Akkadian Empire, the south Mesopotamian region was dominated by the Gutian people for a few decades before the rise of the Third Dynasty of Ur, which encompassed the whole of Mesopotamia, including the town of Babylon.