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Grenades: More likely to kill you than your enemies, and is terrible to aim - especially since manual aiming is apparently a thing of fantasy. Skip it.
My usual loadout (by room 10) is one axe, one flamethrower, and one rocket launcher. I sell everything else.
Rocket Launcher: One of the best weapons in the game. Even if it deals basically nothing, its unique (UNIQUE) status as a ranged weapon means that you can just stand in one place and kill a hydra. You might have to dodge every so often, and you'll have to deal with recoil, but it's a priceless weapon. Always keep one on your person.
(cont)
Katana: Useful in a pinch, but the fact that it teleports you to random enemies means that it's unreliable for normal use. I usually sell it unless it's got REALLY good stats.
(cont)
By the late game, you'll have enough money taht you can afford anti-stun potions. This basically means that stunners are a complete joke, and the only real threat is the flying guy.
In regards to weapons, here are my thoughts:
Axe: Completely normal weapon. Predictable. Useful if it has good stats and stuff, but nothing inherently of use in axes in general.
Dagger: Its stealth ability is incredibly useful if you want to pick enemies off one by one, or if you want to take out the elite in the room relatively quickly. This is usually my main, if I can get my hands on one earlygame that isn't terrible.
(cont)