Prestige plays important role in the game, it is not just to measure your score.

Here is a list of the most important nodes on the map so you can plan your path even while playing for the first time:

Gratious Princess

• (Prestige >=150): +50 Gold, +25 Prestige, -1 Boredom, +2 Ink
  
• (Prestige >=150): +50 Gold, +25 Prestige, +2 HP, +2 Max HP
  
• (Prestige >=400): +75 Prestige, +3 HP, +3 Max HP, +3 Ink
  
• +50 Gold, +25 Prestige, -1 Boredom, +5 HP

Scriptorium

• +2 Ink
  
• (Prestige >= 200): +3 Ink
  
• (Prestige >= 400): -50 gold, +5 HP, +2 Max HP, +4 Ink
  
• +25 Prestige, -2 Boredom, +5 HP

Alehouse

• +5 HP, +2 Max HP
  
• (Prestige >= 200): +8 HP, +3 Max HP
  
• (Prestige >= 400): -50 Gold, +8 HP, +4 Max HP, +2 Ink
  
• +50 Prestige, +10 HP

Inkulnati guild

• +1 Boredom, +2 HP, +2 Max HP, +2 Ink
  
• +15 Prestige, -3 Boredom, +3 HP
  
• (Prestige >=200):+1 Boredom, -2 HP, +3 Max HP, +3 Ink
  
• (Prestige >= 400): -150 Prestige, +1 Quill

Jugglers

• -2 Boredom
  
• -30 Gold, -3 Boredom, +3 HP
  
• (Prestige >= 250): -80 Gold, +25 Prestige, -4 Boredom, +5 HP

Tree

• -1 Boredom, +5 HP
  
• -15 Gold, -2 Boredom, +8 HP
  
• (Prestige >=200): -50 Gold, -2 Boredom, +8 HP, +2 Max HP

Store (Quill costs 300, Beasts and Talents cost 100+, +HP and -Boredom cost below 100 Gold)

• Show
  
• (Prestige >= 300): -75 Prestige, 50% discount
  
• +25 Prestige

Wayside chapel

• -2 Boredom
  
• +5 HP
  
• +25 Prestige

Other nodes can depend on act, but just for reference:

Battle for Beast

• +30 Prestige, +20 Gold, +Beast

Lair

• +40 Prestige, +30 Gold, +Hand Action or +Talent

Usual fight

• +5 Prestige, +25 Gold

No boredom fight (uses 5 best beasts)

• +35 Prestige, +20 Gold

Bard

• -10 gold +25 prestige
  
• -20 gold + 50 prestige
  
• +150 gold if over 399 prestige
  
• -1 boredom + 5 HP

Alchemist

• -2 Health, +3 Ink
  
• +3 Health, -1 Ink
  
• +1 Quill, -3 Ink
  
• +50 Prestige, +5 HP