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I'm assuming you meant drain and blood. I never tried them together so I have no idea how they would work, since they both draw their power from different sources. I never use either of them so I never tried that combo. I found blood tends to kill you, and is really bad because of how hard it is to recover health in this game, and drain pointless because it's already pretty easy to get lots of mana regen, and stamina is far more import being used to run away from enemies. I suppose if you play a class that has awful reduced mana regen, then maybe you could use drain, but its still very situational, and i would still never use blood.
How do you reckon the Stamina and Drain runes would combo? Is there a potential use case for them as a set together?
I noticed I skipped over adding seek for some reason, I had it listed in my notes under A so I went and added it to the guide. I mentioned seek several times under other runes, but I guess i missed adding it's own category lol. I also added an edit note to manifest mentioning that it creates zombies on corruption spells. Thanks for pointing it out.
The seek rune is pretty good, though i think the chain reaction is a better replacement if you have it avalible since it will continue on after killing an enemy to another nearby enemy while seek would just end at the enemy it killed. I agree with you about manifest, after writing this guide I happened to play a corruption only campaign and had nothing better to stick on one of my spells and threw manifest on there, and I happened to learn it makes zombies. Although that is insanely cool, it's only useful on corruption spells and if you're going for achievements will rarely be used. Also I've found that sometimes the zombies bug out and attack the player, even though they're not supposed to.
Otherwise, great guide!