To fix DX12 mode for this game (it works only once, than if you re-launch the game it will crash every single time) do the following:

• Delete all *.ushaderprecache files from %LocalAppData%\VenusPrototype\Saved
  
• Launch the game for the first time in DX12 mode (it will run fine first time), and then quit
  
• Enter %LocalAppData%\VenusPrototype\Saved directory
  
• Protect D3DDriverByteCodeBlob.ushaderprecache as Read Only

Now the game will start in DX12 mode without issues on next launches.
If you change gfx card probably you'll need to regenerate *.ushaderprecache files deleting old ones first...

Enjoy!