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Horse Tranquilizer

if true, it could be because of the math.random calls; you're supposed to use GetCollectibleRNG for the item in question so you don't pollute the global RNG

hmm.... I don't know why it would do that, but it's been a while since I've done anything with my isaac mods, I might take a look at it later.

It could just be that item mods in general change item generation, but idk.

Seems like this changes the item generation for all items in the run, so that a seed with or without the mod will have different items occur with the same level generation. Bummer, since I found a Rock Bottom, Technology, Toxic Shock basement 1 seed when using this mod.

not sure if horse pill variants of custom pill effects can be made, if so then it should probably work fine.

basically there are 13 different pill colors and at the start of a run random effects are assigned to each color, there are horse pill variants of each color that activate a more potent effect.
If they've updated the API to allow custom horse effects to be created then I would imagine it works just fine, unless you're referring to custom pill colors, but I'm not sure if that's a thing.

However, some custom pills are simply cards(such as the Daily Dose) and would have to have an exception created for them, which I am not going to go out of my way to do.

What if... Custom Pills?

it seems that it breaks echo chamber i try to see what would happen but it only activates the effect of the pill i use not the rest

K E T A M I N E .

ah ok, thought maybe i screwed something up

i just wanted to make sure since it wasnt in the desc, thats all

yes, it should be. is there something that made you think otherwise?