When it comes to the base campaign the runes I use are pretty Simple!

Equipment Fiend
Dazed and Confused
Punch and Reave

These runes help with keeping your health and armor up! by using these runes you will have more chances to use your grenades, ice bomb, and flame belch

I can switch out Punch and Reave with Other runes like
Chrono Strike
In air mobility
Saving Throw
or any other rune

I use every weapon mod, but some more than others but here are some that i go for early game

Combat Shotgun: Sticky Bomb and Full Auto
Heavy Cannon: Mirco Missiles
Plasma Rifle: Heat Blast
Rocket Launcher: Lock On Burst
Ballista: Arbalest
Chaingun: Energy Shield


Every Weapon Mod has its uses and weaknesses but never let the weaknesses scare you into trying out new things!

My key bindings for weapons goes as follows!

(keep in mind i have a multi button mouse so if you dont have one of those you'll have to figure something out yourself sadly)

Combat Shotgun = 1
Heavy Cannon = 2
Plasma Rifle = 3
Rocket Launcher = V
Super Shotgun = F
Ballista = Q
Chaingun = C
BFG/Unmakyr = G
Crucible = Mouse 5
Chainsaw = Mouse Wheel Down
Glory Kill/Blood Punch/Use = Mouse 4
Grenade/Ice Bomb = Z
Switch Grenade/Ice Bomb = X
Dash = LShift
Switch Weapon Mod = R
Flame Belch = E

So yeah try these binds out, and if they work for you feel free to reward this guide! it would really mean a lot to me =)

I focus a lot on keeping my health and armor high, and keeping my equipment ready
this just how i play, no one should have to play how i do! im just explaining my play style!

i like to describe my play style as this

"A Symphony of Destruction"