Yuyushiki (Japanese: ゆゆ式) is a Japanese 4-panel manga series written and illustrated by Komata Mikami, which began serialization in Houbunsha's Manga Time Kirara magazine from April 2008 issue. An anime television adaptation by Kinema Citrus aired in Japan between April and June 2013. An original video animation was released on February 22, 2017. The series' name is derived from the term "yuyushiki jitai" (由々しき事態, lit. "in a serious situation").

The series follows the daily lives of three high school girls: the intelligent but childish Yuzuko, the kind but airheaded Yukari, and the mature and easily irritated Yui, who are all part of their school's Data Processing Club (情報処理部, Jōhōshori-bu). As the girls spend their days having meaningless discussions, they occasionally come up with topics to research while in their clubroom.

The original manga by Komata Mikami began serialization in Houbunsha's Manga Time Kirara magazine from April 2008.The first tankōbon volume of the manga was released March 26, 2009, and twelve volumes have been published as of November 26, 2021.

The anime television adaptation is produced by Kinema Citrus and is directed by Kaori. Series composition is done by Natsuko Takahashi and character design by Hisayuki Tabata. The series aired between April 9 and June 26, 2013 and was simulcast with by Crunchyroll. The opening theme is "One Two!" (せーのっ!, Sēno!) by Rumi Ōkubo, Risa Taneda and Minami Tsuda, while the ending theme is "Affection" by Mayumi Morinaga. Sentai Filmworks licensed the series in North America and released it on subtitled DVD on July 1, 2014. An original video animation episode was released in Japan on February 22, 2017.[13] The opening and ending themes respectively are "Kirameki! no Hi" (きらめきっ！の日, A Sparkling Day!) and "Aozora no Tsukurikata" (青空のつくりかた, How to Make a Blue Sky), both performed by Ōkubo, Tsuda, and Taneda.