Now that I've finally 100%'d this game I feel like I can give a review...
To me there's 2 ways you can play Binding of Isaac.
1. Enjoy the dungeon crawler for what it is, play through a couple of times maybe beat every end boss at least once and call it a day.
OR
2. Spend a 1000 hours trying to get every ending with all 34 characters on the hardest difficulty forcing you to memorize all enemy attack patterns, every map mechanic, every item effect, every transformation effect and items that produce them. And watch as your sanity slowly deteriorate as your mental state and Isaac die thousands of times all in pursuit of the Dead God achievement.

Both are valid and both give a uniquely challenging roguelike dungeon crawling experience that I recommend to anyone looking for a solid game to play. 10/10

Now that I've finally 100%'d this game I feel like I can give a review... To me there's 2 ways you can play Binding of Isaac. 1. Enjoy the dungeon crawler for what it is, play through a couple of times maybe beat every end boss at least once and call it a day. OR 2. Spend a 1000 hours trying to get every ending with all 34 characters on the hardest difficulty forcing you to memorize all enemy attack patterns, every map mechanic, every item effect, every transformation effect and items that produce them. And watch as your sanity slowly deteriorate as your mental state and Isaac die thousands of times all in pursuit of the Dead God achievement. Both are valid and both give a uniquely challenging roguelike dungeon crawling experience that I recommend to anyone looking for a solid game to play. 10/10