The spice trade refers to the trade between historical civilizations in Asia, Northeast Africa and Europe. Spices such as cinnamon, cassia, cardamom, ginger, pepper, and turmeric were known and used in antiquity for commerce in the Eastern World.[1] These spices found their way into the Middle East before the beginning of the Christian era, where the true sources of these spices were withheld by the traders and associated with fantastic tales.[1] Early writings and stone age carvings of neolithic age obtained indicates that India's southwest coastal port Muziris, in Kerala, had established itself as a major spice trade centre from as early as 3000 BC, which marked the beginning of the spice trade. Kerala, referred to as the land of spices or as the "Spice Garden of India", was the place traders and explorers wanted to reach, including Christopher Columbus, Vasco da Gama, and others.