The Doctor first appears at the Admiral Benbow Inn There, he assists the unconscious Billy Bones who had recently suffered a stroke. Prior to this, Bonesalready trusted the doctor so he recommended that Jim Hawkins "jump to the doctor" in an emergency. Shortly after arrival, Livesey cheerfully warns Bones to quit his addiction to rum or else he would meet his fate.

Upon arriving at Squire Trelawney's mansion, Jim informs the doctor and Trelawney about the treasure map that formerly belonged to Captain Flint Having received the map, Livesey and Trelawny decide to start recruiting a team to organize an expedition to the island.

Later, when Jim finds out about the betrayal of the crew of the Hispaniola led by Long John Silver he tells his crew about Silver's plan of rebellion. Livesey and the others manage, despite artillery fire, to leave the ship guarded by pirates and move to the island. Jim and his crew occupy the fort and move to the defense of the position. During the absence of Jim, who left to search for the treasure within the island, Livesey Trelawney and Captain Smollett steal a rowboat to take refuge at an abandoned fortress where they would win in a shootout against Silver's pirates after Trelawney tricks them to fall off a cliff.

After Jim gets captured by Silver after sneaking aboard his ship, Silver reveals that Livesey and Ben Gunn had already given the map for the treasure, unaware that the two had already found the treasure earlier that day. Later, when the pirates go looking for treasure in accordance to the map, Livesey sets up a trap with the rest of Jim's crew and drives the surviving pirates to drop dead with a demonstration of the dangers of smoking. After loading the treasure on the ship, he returns to England with the others.